Ayah
Word by Word
إِنَّ
Indeed
رَبَّكَ
your Lord
هُوَ
He
أَعۡلَمُ
knows best
مَن
who
يَضِلُّ
strays
عَن
from
سَبِيلِهِۦۖ
His way
وَهُوَ
and He
أَعۡلَمُ
(is) most knowing
بِٱلۡمُهۡتَدِينَ
of the guided-ones
إِنَّ
Indeed
رَبَّكَ
your Lord
هُوَ
He
أَعۡلَمُ
knows best
مَن
who
يَضِلُّ
strays
عَن
from
سَبِيلِهِۦۖ
His way
وَهُوَ
and He
أَعۡلَمُ
(is) most knowing
بِٱلۡمُهۡتَدِينَ
of the guided-ones
Translation
Thy Lord knoweth best who strayeth from His way: He knoweth best who they are that receive His guidance.
Tafsir
Your Lord knows best those who stray from His way and He knows well the rightly guided, and will requite both of them.
Most People are Misguided
Allah says;
وَإِن تُطِعۡ أَكۡثَرَ مَن فِي الَارۡضِ يُضِلُّوكَ عَن سَبِيلِ اللّهِ
And if you obey most of those on the earth, they will mislead you far away from Allah's path.
Allah states that most of the people of the earth, are misguided.
Allah said in other Ayat,
وَلَقَدۡ ضَلَّ قَبۡلَهُمۡ أَكۡثَرُ الاٌّوَّلِينَ
And indeed most of the men of old went astray before them. (37:71)
and,
وَمَأ أَكۡثَرُ النَّاسِ وَلَوۡ حَرَصۡتَ بِمُوۡمِنِينَ
And most of mankind will not believe even if you eagerly desire it. (12:103)
They are misguided, yet they have doubts about their way, and they rely on wishful thinking and delusions.
إِن يَتَّبِعُونَ إِلاَّ الظَّنَّ وَإِنۡ هُمۡ إِلاَّ يَخۡرُصُونَ
They follow nothing but conjecture, and they do nothing but lie.
Thus, they fulfill Allah's decree and decision concerning them
إِنَّ رَبَّكَ هُوَ أَعۡلَمُ مَن يَضِلُّ عَن سَبِيلِهِ
Verily, your Lord! It is He Who knows best who strays from His way.
and facilitates that for him,
وَهُوَ أَعۡلَمُ بِالۡمُهۡتَدِينَ
And He knows best the rightly guided.
He facilitates that for them, all of them are facilitated for what He created them.
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